Distribute the diced jalapenos through the shredded Pepper Jack in a mixing bowl. The pepper pieces should appear throughout the cheese rather than collecting at the bottom.
Compress portions firmly between your palms into approximately 1-inch balls, arrange them on a parchment-lined tray, and freeze for about 30 minutes. The shaped portions should feel firm enough to handle without shedding cheese.
During the freezer rest, arrange flour in one bowl, beaten eggs and milk in another, and breadcrumbs mixed with cayenne, paprika, salt, and garlic powder in a third. The egg wash should look uniform, with the spices evenly dispersed through the crumbs.
Bring vegetable oil to 375°F (190°C) in a deep fryer or large pot, checking it with a thermometer. A steady temperature reading is a better readiness cue than the oil’s appearance.
Take the firm balls from the freezer and coat each with flour, followed by egg wash and then seasoned breadcrumbs. Turn each bite to check for exposed cheese and press crumbs onto any thin patches.
Lower the coated bites into the oil in uncrowded batches and cook for 2 to 3 minutes. Look for a deep golden crust as the rapid bubbling begins to ease slightly.
Lift the golden bites with a slotted spoon and transfer them to a plate lined with paper towels. Excess surface oil should drain away while the coating stays intact.
Bring the freshly fried bites to the table while hot. The crust should feel crisp around a soft, melted cheese center.