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Golden chicken bubble biscuit bake casserole topped with a savory garlic-parmesan herb brush finish.

Easy Chicken Bubble Biscuit Bake Casserole

Rebecca Blumer
A creamy, cheesy comfort food classic that uses rotisserie chicken and refrigerated biscuit bubbles for a quick and satisfying weeknight dinner the whole family will love.
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Prep Time 10 minutes
Cook Time 35 minutes
Total Time 45 minutes
Course Main Course
Cuisine American
Servings 6 Servings
Calories 485 kcal

Equipment

  • 9x13 inch baking pan
  • Large Mixing Bowl

Ingredients
 

  • 3 cups cooked chopped chicken or canned chicken
  • 2 cans cream of chicken soup
  • 1 1/2 cups sour cream
  • 1 cup grated cheese
  • 2 Tablespoons Ranch dressing mix
  • 1/4 cup cooked chopped bacon
  • 1 12 oz can refrigerator Grands Jr Biscuits
  • 1 cup additional grated cheese for top of casserole

Instructions
 

Preheat and prep the pan

  • Preheat your oven to 350°F. Lightly spray a 9x13-inch baking pan with non-stick cooking spray and set it aside.

Mix the creamy chicken filling

  • In a large mixing bowl, combine the cooked chopped chicken, cream of chicken soup, sour cream, 1 cup of grated cheese, Ranch dressing mix, and the cooked chopped bacon. Stir until well combined.

Create the biscuit bubbles

  • Open the can of biscuits and cut each individual biscuit into 4 equal pieces. Add these biscuit pieces to the bowl with the chicken mixture and toss gently until every piece is coated.

Assemble and bake

  • Pour the entire chicken and biscuit mixture into the prepared 9x13-inch pan, spreading it into an even layer. Sprinkle the remaining cup of grated cheese over the top.
  • Bake for 25 to 35 minutes. The casserole is ready when the edges are bubbling and the biscuit tops have turned a deep golden brown.

Notes

Safety Tip: Use a meat thermometer to ensure the center of the casserole reaches 165°F. This guarantees the biscuit dough is fully cooked and fluffy throughout.
Preparation Tip: You can prepare the creamy chicken filling up to 24 hours in advance. To keep the texture light, wait to cut and add the refrigerated biscuits until just before you are ready to bake.
Storage Tip: Reheat leftovers in a 350°F oven rather than the microwave. This helps the biscuit bubbles regain their golden crispness instead of becoming soft.
Nutrition information is estimated based on common ingredients and serving sizes and may vary.

Nutrition

Calories: 485kcalCarbohydrates: 32gProtein: 26gFat: 29gSaturated Fat: 15gCholesterol: 95mgSodium: 1280mgPotassium: 365mgFiber: 1gSugar: 4gVitamin A: 12IUVitamin C: 2mgCalcium: 280mgIron: 2mg
Keyword chicken bubble biscuit bake casserole, Comfort Food, Easy Dinner
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